In a similar way to the Sava River, the Tisza is one of the main tributaries of the Danube. However, whereas the Sava is the largest waterway to meet with this popular European river, the Tisza is the longest. In the past, it flowed entirely within the borders of Hungary, leading to it being known as 'The most Hungarian River', however today it crosses into Ukraine, Serbia, Romania and Slovakia too.

In order to prevent major flooding, the Tisza was effectively straightened in the period between 1846 and 1880. Many of the twists and turns were removed so that the river flowed faster and flooded less often. Another flood prevention tactic, the building of the Tisza Dam in 1970, lead to the creation of Lake Tisza, a popular tourist destination in the area. People also embark on Tisza River cruises to see the large concentration of birdlife that lives here, as well as the annual 'flowering of the Tisza'.

Itineraries usually include stops along the Danube and Sava rivers and will feature visits to Tisza ports like Szeged, Csongrad and Tokaj. Szeged is known as the sunshine city, whilst Csongrad will offer a look into Hungary's national history, as well as a visit to a paprika farm, and Tokaj provides the chance to try some of Hungary's famous dessert wine of the same name.